Covalently Cross-Linked Particles Based on Arabinoxylans: Antioxidant Activity and Cytotoxicity on a Human Colon Cell Line

Polysaccharide-based carriers have become attractive materials for the delivery of therapeutics targeting colon. Ferulated arabinoxylans (AX)—polysaccharides with gelling and antioxidant capacities that can be degraded by colonic microbiota—are ideal candidates use as oral drug systems [1]. Recently, AX-based microspheres demonstrated potential applications colon-targeted [2,3]. The non-cytotoxicity is a required property their biomaterial. This study reports activity cytotoxicity on human colon cells covalently cross-linked particles based AX (AXP). in vitro before after gelation was measured using 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS+), 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing power (FRAP) methods. effect AXP proliferation (CCD 841 CoN) evaluated MTT assay. presented spherical shape rough surface three-dimensional porous network. Gelation decreased 61–64%. did not affect or show any toxic regular cell line CCD CoN. results indicate are promising biocompatible activity. could suitable development